Memory, dementia, mood and the aging brain.
In a first-in-human trial in 79 healthy adults, the oral drug VES001 was well tolerated and raised levels of progranulin, a protein that is too low in one genetic form of frontotemporal…
A systematic review of 42 studies, published in October 2026 in Alzheimer's & Dementia, found that social isolation and loneliness are linked to partly different brain regions, and both to more white…
In the HIMALAYA trial of 305 people with ALS in 13 countries, the RIPK1 inhibitor SAR443820 did not slow functional decline over 24 weeks and caused more liver enzyme increases than placebo.
A study of 302 dementia-free older adults in Southeast Asia, published in October 2026 in Alzheimer's & Dementia, found that narrower small arteries in the retina were linked to a higher chance…
In a study of ninety-three women aged 35-63, published Oct. 27, 2026, in Medicine & Science in Sports & Exercise, those who exercised regularly showed less age-related slowing in reaction time and…
A review of fourteen studies in adults aged 60 or older found that probiotics, prebiotics and synbiotics improved global cognition scores by 1.28 points in a pooled subgroup, though the studies were…
In a randomized trial of 86 family caregivers of people with dementia, a mobile app designed with caregivers' input improved their overall and psychological quality of life at 8 weeks, but did…
In a randomized trial published Oct. 28, 2026, in JAMA Psychiatry, a mindfulness program for opioid use disorder shifted brain activity away from drug cues toward natural rewards, reduced craving and extended…
In a phase 2b trial published Oct. 26, 2026, in JAMA, one intranasal dose of mebufotenin cut depression scores more than a very low dose at day 29 in adults with treatment-resistant…
A meta-analysis of sixteen randomized trials with 1992 participants found that psychodynamic psychotherapy lasting at least nine months reduced depressive symptoms compared with other conditions, with effects generally sustained.
In 486 intensive care patients with traumatic brain injury and anemia, transfusing at a higher hemoglobin threshold was linked to fewer poor neurological outcomes at 180 days than a restrictive strategy, though…
A real-world study of 181 people with Alzheimer's in China, published in October 2026 in Alzheimer's & Dementia, found that responses to lecanemab emerged at 6 months, mostly in early disease, and…
In the INFRONT-3 phase 3 trial, published in October 2026 in Alzheimer's & Dementia, latozinemab raised progranulin levels in people with frontotemporal dementia from GRN mutations, but didn't slow the disease over…
A review published Oct. 29, 2026, in The Lancet explains irritable bowel syndrome and related gut-brain disorders, which affect 20% of the world's population, and what helps: education, diet, fiber, targeted drugs…
A study of 10,375 Europeans followed for up to 18 years, published in October 2026 in Alzheimer's & Dementia, found that poorer hearing, loneliness and weaker memory go together, but found little…
A meta-analysis of 21 studies estimated the global prevalence of frontotemporal dementia, a leading cause of dementia before age 65, at 30 cases per 100,000 people, with extreme differences between studies.
In a study of 136 older adults published Oct. 30, 2026, in GeroScience, delayed recall on a face-name memory test told apart people with mild cognitive impairment about as well as the…
A network meta-analysis of thirty-eight randomized trials, published Oct. 20, 2026, in PeerJ, found that moderate exercise doses, about 300 to 1,000 MET-minutes a week, gave the most reliable gains in executive…
A preregistered analysis of 40 brain-imaging datasets with 2,175 participants, published Oct. 28, 2026, in Nature, found that common measures of how well people reframe emotions didn't agree with each other or…
In the HEALEY ALS Platform Trial, 325 participants took DNL343 or placebo for 24 weeks. The drug, which targets the cell's integrated stress response, did not slow loss of function or improve…
