In a study of 481,857 adults who had overnight sleep studies, published Oct. 15, 2026, in Sleep, periodic leg movements during sleep were linked to depression, insomnia, high blood sugar and anemia,…
A study of 4,162 US adults, published Oct. 7, 2026, in Frontiers in Public Health, found that waking three or more times a night to urinate was linked to higher odds of…
A study of 98 people in Xinjiang, China, published Oct. 23, 2026, in Psychoneuroendocrinology, found mild but consistent differences in the functions of gut bacteria in people with major depression, including pathways…
In a phase 2b trial published Oct. 26, 2026, in JAMA, one intranasal dose of mebufotenin cut depression scores more than a very low dose at day 29 in adults with treatment-resistant…
A meta-analysis of sixteen randomized trials with 1992 participants found that psychodynamic psychotherapy lasting at least nine months reduced depressive symptoms compared with other conditions, with effects generally sustained.
Pooling double-blind trials in adults with depression, escitalopram and amitriptyline lengthened the QTc interval, a heart rhythm measure, more than placebo. Antidepressants were not linked to more early major heart events.
